Zynamite^®

Zynamite^® for mental & physical energy

Zynamite^® is Nektium’s award-winning, patented proprietary Mangifera indica extract. Infusions and decoctions of mango leaves are used extensively in traditional health systems for their multiple benefits.

Zynamite^® is the result of a five year long global research quest for the next-generation mental & physical energy ingredient

Zynamite^® is an all-natural evidence-based nootropic and sports performance ingredient, supported by seven clinical studies.

Zynamite^® is used to energize mental and physical performance formulations.

Zynamite^® at a glance

• 7 clinical studies
• 6 peer reviewed publications
• Patented: Compositions for enhancing brain activity (US10537604B2)
• 2 patents pending: for sports performance and anti-craving
• 5 global industry awards, for research, innovation, and sports.
• Fast-acting & long lasting
• Mechanisms of action entirely different to caffeine
• Side-effect free
• Self-affirmed GRAS
• Natural, clean label

Zynamite^® nootropic activities

• Activates brain electrical activity
• Increases long term potentiation
• Faster reaction time and increased calculation performance
• Decreased fatigue

Zynamite^® for sports performance

Tested in repeat sprint exercise as well as exercise during simulated exhaustion (ischaemia-reperfusion model) in men and women.

• Increased peak power output
• Increased mean power output
• Increased VO₂max
• Increased brain oxygenation in women
• Increased muscle oxygen extraction
• Decreased lactate

Zynamite^® for sport recovery

The effect on pain and recovery was studied after a 10km race followed by 100 drop jumps, demonstrating the following results:

• Accelerated recovery of muscle performance
• Reduced pain and muscle damage elicited by competitive exercise

Push past your limits

Zynamite^® is an ingredient that delivers mental energy and supports the mental and physical aspects of sports performance. Clinical studies of formulations containing Zynamite^® significantly improves both peak power output and mean power output in fatigued and exhausted men and women – that place where athletes find themselves when they need your help the most.

Faster reaction and quicker adaptation to changing conditions are essential to high performance athletics. The cognitive benefits of Zynamite^® combined with the physical make this ingredient a unique solution for athletes, e-sports, shift workers, truck drivers and every person in need of mental and physical energy.

Intriguingly, in vivo studies of Zynamite^® have pointed to the potential for synergies between Zynamite^® and low doses of caffeine, suggesting that formulations that combine these ingredients will be attractive to consumers. This sets up exciting formulating options that include both ‘stim’ and ‘non-stim’ products.

Peer reviewed publications

Dimpfel, W., et al. Zynamite^®(Mangifera indica leaf extract) and Caffeine Act in a Synergistic Manner on Electrophysiological Parameters of Rat Central Nervous System. Food and Nutrition Sciences, 9, 502-518 (2018).

Gelabert-Rebato, M., et al. Enhancement of Exercise Performance by 48 Hours, and 15-Day Supplementation with Mangiferin and Luteolin in Men. Nutrients, 11 (2), 344 (2019).

Gelabert-Rebato, M., et al. Mangifera indica L. leaf Extract (Zynamite^®) in Combination with Luteolin or Quercetin Enhances VO₂peak and Peak Power Output, and Preserves Skeletal Muscle Function During Ischemia-Reperfusion in Humans. Front. Physiol. 9, 740 (2018).

Gelabert-Rebato, et al. A Single Dose of The Mango Leaf Extract Zynamite^® in Combination with Quercetin Enhances Peak Power Output During Repeated Sprint Exercise in Men and Women. Nutrients, 11 (11), 2592 (2019).

Reddeman, R.A., et al. A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin. Journal of toxicology, (2019).

Martin-Rinco, M., et al. Supplementation with a Mango Leaf Extract (Zynamite^®) in Combination with Quercetin Attenuates Muscle Damage and Pain and Accelerates Recovery After Strenuous Damaging Exercise. Nutrients (2020).

Wightman, E., et al. Acute Effects of a Polyphenol-Rich Leaf Extract of Mangifera indica L. (Zynamite^®) on Cognitive Function in Healthy Adults: A Double-Blind, Placebo-Controlled Crossover Study. Nutrients (2020).

Zynamite^® is protected

• Compositions for enhancing brain activity
  (Patent US 10537604B2)
• Compositions for reducing craving, enhancing mood
  & decreasing stress (Patent ES 2681996B2)
• Compositions for improving sports performance
  (Patent Application PCT/EP 2018/084023)