For mental and physical energy
Zynamite® is our natural and clean label ingredient, formulated to deliver mental and physical stimulation.
Side effect free, this patented ingredient supports faster reaction times, speeds up mental activation and helps to increase performance and recovery. Zynamite® has won numerous global industry awards for research, innovation, and sports.
Supported by so far 9 human trials, 8 publications and 3 patent families, Zynamite® provides multiple benefits, both for nootropic as well as for sports performance & recovery.
Several years ago, we set out on a mission to find an all-natural mental and physical energy ingredient that could be used as an alternative to caffeine.
Amongst others, we discovered the potential of the leaf of Mangifera indica (or mango tree).
From this well-established plant source – rich in mangiferin and other bioactives – we developed a proprietary standardised extract, trademarked as Zynamite®.
After its launch in 2018, today Zynamite® is successfully marketed to the global supplement and functional food industry.
The only clean label and research-proven mango leaf extract globally.
Zynamite® is backed by a large number of studies and is included in numerous research papers.
Zynamite® is as suitable for supplements as for food and beverage applications.
Pre-clinical studies demonstrated, that Zynamite® crosses the blood brain barrier, modulates neurotransmitter response and increases the long-term memory.
Its mechanism of action is mediated by the partial inhibition of COMT (Catecol-O Metil-Transferase), which is a key enzyme that degrades the dopamine, a neurotransmitter that modulates the cognitive function including working memory, planning and attention.
Our human studies demonstrate in addition a variety of benefits to the consumers. Main focus has been on non-stim mental energy and sports performance under physical stress conditions.
Under cognitive stress conditions, Zynamite® modulates the neurotransmitter response, enhancing attention during cognitive task performance, improving reaction time and reducing cognitive fatigue while keeping the heart-rate and blood pressure without change.
Under physical stress conditions Zynamite® formulations improve sports performance variables, acting as an ergogenic modulator. Zynamite® formulations furthermore improve brain oxygenation during physical activity, leading to improved cognitive function. It was also demonstrated that Zynamite® formulations reduce blood lactate levels.
And last but not least, Zynamite® formulations reduce pain perception and accelerate the recovery after strong physical exercise.
Zynamite® has already been incorporated in dietary supplement formats such as tablets, capsules, fizzy sticks and others.
Thanks to our application capabilities we have been able to demonstrate that Zynamite® is stable throughout stringent beverage production processes, with almost no impact on colour and organoleptics.
Several application trials are under way to assure that Zynamite® formulations can be used in all types of functional food formats, allowing our customers to propose the most suitable product formulation to their consumers.
Did you know?
The health benefits of mango leaves were already described
thousand of years ago in ancient Ayurveda Sanskrit verses,
as being beneficial in treating digestive health issues such
as stomach pain, diarrhea and vomiting.
Mangifera indica (leaves)
Nektium Pharma SL holds GMP certification (ES19/85835) and FSSC 22000 Food Safety System Certification (ES19/86276) by SGS
Wightman, E., et al. Acute Effects of a Polyphenol-Rich Leaf Extract of Mangifera indica L. (Zynamite®) on Cognitive Function in Healthy Adults: A Double-Blind, Placebo-Controlled Crossover Study. Nutrients (2020).
López-Ríos, L. et al. Central nervous system activities of extract Mangifera indica L. Journal of Ethnopharmacology, 260, 112996 (2020).
Gelabert-Rebato, et al. A Single Dose of The Mango Leaf Extract Zynamite® in Combination with Quercetin Enhances Peak Power Output During Repeated Sprint Exercise in Men and Women. Nutrients, 11 (11), 2592 (2019).
Martin-Rinco, M., et al. Supplementation with a Mango Leaf Extract (Zynamite®) in Combination with Quercetin Attenuates Muscle Damage and Pain and Accelerates Recovery After Strenuous Damaging Exercise. Nutrients (2020).
Gelabert-Rebato, M. et al. Mangifera indica L. Leaf Extract in Combination With Luteolin or Quercetin Enhances VO2 peak and Peak Power Output, and Preserves Skeletal Muscle Function During Ischemia-Reperfusion in Humans. Frontiers in Physiology, 9, 740 (2018).
Gelabert-Rebato, M. et al. Enhancement of Exercise Performance by 48 Hours, and 15-Day Supplementation with Mangiferin and Luteolin in Men. Nutrients, 11, 344 (2019).
The Nektium Guarantee
From our trusted relationships with our suppliers and ensuring responsible sourcing, to how we carefully treat the raw botanicals at our specialist facilities, we are more than just an ingredients supplier.
We truly understand the fingerprint of our branded ingredients and our expert technical team can support you to adapt them for a wide range of specific needs and uses.
Partner with us to explore the potential of Zynamite®, our premium branded ingredient.
By taking the time to understand your challenges and goals,
we can help you take your products further.