Nektium’s new Vanizem™ botanical extract, derived from the West African spice Aframomum melegueta, can significantly improve mood, reduce stress levels, and enhance sleep quality within just three days, as revealed by a recent pilot study. This placebo-controlled crossover study involved 30 healthy adults aged 40-50, who experienced day-to-day stress. Participants consuming at least 100mg of Vanizem™ saw significant reductions in anxiety and improvements in mood and sleep quality. The extract's efficacy is attributed to its impact on the endocannabinoid system and various receptors related to mood and stress regulation, without causing sedative effects, making it suitable for daily use.